[Pooya/Ali Commentary 68:44] As "mercy unto the worlds" the Holy Prophet desired all human beings to follow the right path and attain salvation, therefore the obstinate deviation, hypocrisy and disbelief of the people made him unhappy. He is advised by Allah not to grieve over the fate of such people. Allah shall deal with them as He wills. He may give them respite for a while (see Ali Imran: 178) or ruin them step by step, as mentioned in Araf: 182. Allah's plan is so decisive that they will never be able to escape from it.